Improved synthesis of N1-substituted orotic acid derivatives.
نویسندگان
چکیده
An improved method for the synthesis of N1-substituted orotic acid derivatives is reported. The method involves sequential incorporation of nitrogen atoms to the pyrimidine structure from simple starting materials and thus allows the synthesis of N1-substituted orotic acid derivatives with single 15N label at either N-1 or N-3.
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ورودعنوان ژورنال:
- Tetrahedron letters
دوره 54 32 شماره
صفحات -
تاریخ انتشار 2013